P V T - I , A Novel Human Transcription Unit Affected by Variant Translocation t ( 2 ; 18 ) ( pl l ; q 21 ) of Follicular Lymphoma
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چکیده
Variant t(2; 18) and t(l8;22) chromosome translocations observed in B-cell chronic lymphocytic leukemias and in follicular lymphomas have been reported to consistently involve the 5 region of the BCL-2 gene on chromosome 18 and various regions on the lg light chain loci. We show here that a variant t(2; 18) (p l l ;q21) translocation observed in a case of follicular lymphoma leads to the juxtaposition of a JK segment to a chromosome 18 transcriptional unit located 1 0 kpb upstream of the BCL-2 locus. The cDNA of this new evolutionarily conserved gene, termed M1 for
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تاریخ انتشار 2003